Aspirin pubchem

Aspirin, also known as acetylsalicylic acid, is a widely recognized compound for its medicinal properties. Its registration on PubChem provides detailed insights into its molecular structure, chemical properties, and biological activities. Discovering this information can enhance your understanding of how aspirin functions within the body.

Utilizing PubChem to research aspirin offers access to valuable data, including its molecular formula (C9H8O4), molecular weight (180.16 g/mol), and classification as a non-steroidal anti-inflammatory drug (NSAID). This comprehensive database also presents information regarding its solubility, which is crucial for understanding dosage and efficacy.

Exploring the biological effects of aspirin through PubChem reveals its role in inhibiting cyclooxygenase enzymes, leading to reduced production of prostaglandins. This mechanism underpins its effectiveness in alleviating pain, reducing inflammation, and lowering fever. Examining various studies linked to aspirin can provide deeper insights into its applications and potential side effects, informing safe usage.

Aspirin PubChem: A Comprehensive Guide

Aspirin, known scientifically as acetylsalicylic acid, offers a wealth of information in the PubChem database. Utilize this resource to explore its properties and applications effectively.

Begin your search in PubChem by entering “Aspirin” in the search bar. This links you directly to a wealth of data. Key sections to explore include:

• Compound Summary: This section provides an overview, including chemical structure, molecular formula (C₉H₈O₄), and molecular weight (180.16 g/mol).
• Safety Information: Access pertinent safety data, including toxicity levels and handling precautions.
• Pharmacological Action: Investigate the anti-inflammatory, analgesic, and antipyretic effects of Aspirin. The mechanism of action is primarily through inhibition of cyclooxygenase (COX) enzymes.
• Biological Activities: Review the various biological targets associated with Aspirin. This covers its role in cardiovascular health and cancer prevention strategies.

For practical applications, the database provides detailed routes of synthesis and metabolism, showcasing how Aspirin is processed in biological systems.

If researching interactions, the PubChem page includes a list of potential drug interactions, vital for anyone prescribing or taking Aspirin alongside other medications.

Utilize the PubChem’s extensive links to literature, where you can find studies and clinical trials relevant to Aspirin’s efficacy and safety.

For further understanding, examine the “Regulatory Status” section where you can find information about its approval and use in different countries.

Aspirin’s data on PubChem serves not only researchers but also healthcare professionals and students seeking to deepen their knowledge about this widely used medication.

Chemical Structure and Properties of Aspirin

Aspirin, or acetylsalicylic acid, is characterized by its unique chemical structure, which comprises a benzene ring, a carboxylic acid group, and an ester functional group. The molecular formula is C₉H₈O₄, and its systematic name is 2-(acetyloxy)benzoic acid. The presence of the acetyl group differentiates it from salicylic acid, enhancing its anti-inflammatory and analgesic properties.

The three-dimensional configuration of aspirin reveals how the molecules interact. It exhibits a specific stereochemistry where the acetyl group is oriented in such a way that maximizes the compound’s interaction with the cyclooxygenase enzymes, responsible for pain and inflammation pathways in the body.

Physical Properties

Aspirin appears as a white, crystalline powder with a melting point of approximately 135 °C. It is slightly soluble in water but readily dissolves in organic solvents like ethanol and acetone. The pH of an aspirin solution can range from 3 to 4, highlighting its weak acid nature. These properties influence its availability and absorption in biological systems, impacting therapeutic efficacy.

Stability and Storage

Aspirin should be stored in a cool, dry place, away from light and moisture to maintain its stability. Its degradation can occur in the presence of humidity, leading to the formation of salicylic acid and acetic acid, which may result in reduced efficacy and altered taste. Proper storage practices ensure that aspirin retains its desired properties for effective use.

Aspirin’s Role in Medicine: Mechanisms and Uses

Aspirin, or acetylsalicylic acid, acts primarily as an analgesic, anti-inflammatory, and antipyretic agent. It inhibits the enzyme cyclooxygenase (COX), which reduces the synthesis of prostaglandins–compounds involved in pain and inflammation. This mechanism makes aspirin effective in managing conditions like arthritis and muscle pain.

In addition to pain relief, aspirin plays a significant role in cardiovascular health. It acts as an antiplatelet agent, preventing blood clots by inhibiting platelet aggregation. Healthcare providers often recommend low-dose aspirin therapy for individuals at risk of heart attacks or strokes, as it can reduce the likelihood of these events by maintaining better blood flow.

Aspirin also demonstrates benefits in managing fever. By acting on the hypothalamus, it helps lower body temperature during febrile illnesses, providing comfort to patients. For those with conditions like rheumatoid arthritis, aspirin’s anti-inflammatory properties can significantly enhance quality of life.

Recent studies suggest that aspirin may have protective effects against certain types of cancer, particularly colorectal cancer. Regular use has been associated with a reduced risk of tumor development, although individuals should consult healthcare professionals before starting any long-term regimen.

Despite its benefits, aspirin is not suitable for everyone. Potential gastrointestinal side effects, like ulcers and bleeding, necessitate caution. Also, individuals with certain medical conditions or those on specific medications must consult with healthcare providers before using aspirin.

Aspirin remains a cornerstone in various therapeutic settings, offering significant, well-documented benefits. Understanding its mechanisms and appropriate use can enhance treatment strategies and improve patient outcomes.

Exploring Aspirin’s Pharmacokinetics and Pharmacodynamics

Aspirin is rapidly absorbed after oral administration, reaching peak plasma concentration within 1 to 2 hours. The bioavailability typically ranges from 40% to 50%, influenced by food intake and the formulation used. For optimal absorption, take aspirin on an empty stomach.

Once in the bloodstream, aspirin undergoes hydrolysis to salicylic acid, its active metabolite. Salicylic acid contributes to aspirin’s anti-inflammatory effects and its ability to inhibit cyclooxygenase (COX) enzymes, leading to decreased synthesis of prostaglandins and thromboxanes. This mechanism explains aspirin’s pain-relieving and antipyretic properties.

After administration, the volume of distribution is approximately 0.1 to 0.2 L/kg, indicating a moderate extent of distribution into tissues. Aspirin is highly protein-bound, primarily to albumin, which can impact its free concentration in the plasma. Monitor for drug interactions that may alter its protein-binding capacity.

The elimination half-life of aspirin ranges from 15 to 20 minutes, while salicylic acid has a longer half-life of 2 to 3 hours at low doses. As dosage increases, the half-life of salicylic acid can extend significantly due to saturation of metabolic pathways, necessitating careful dose management.

Aspirin’s pharmacodynamics include irreversible inhibition of platelet aggregation, making it effective for cardiovascular protection. The antiplatelet effect persists for the lifespan of the platelet, approximately 7 to 10 days. Thus, initiate low-dose aspirin therapy for those at risk of cardiovascular events as a preventive measure.

Assess renal function, as aspirin’s renal clearance may decrease in cases of impaired kidney function, leading to toxicity. Regular monitoring of patients on long-term aspirin therapy helps mitigate adverse effects and ensures safe use.

Understanding aspirin’s pharmacokinetics and pharmacodynamics enhances effective therapeutic strategies while minimizing risks. Tailor dosages based on individual health profiles to achieve desired outcomes safely.

Safety Profile and Potential Drug Interactions of Aspirin

Aspirin displays a solid safety profile when used as directed, yet its potential for adverse effects necessitates caution. Common side effects include gastrointestinal irritation, bleeding, and allergic reactions. Individuals with a history of peptic ulcers, gastrointestinal bleeding, or asthma should avoid aspirin unless under medical supervision.

Drug Interactions to Consider

Aspirin interacts with several medications, impacting their effectiveness or increasing the risk of side effects. Nonsteroidal anti-inflammatory drugs (NSAIDs) can heighten the risk of gastrointestinal bleeding when used together with aspirin. Anticoagulants like warfarin or direct oral anticoagulants enhance bleeding risks significantly; therefore, careful monitoring is essential.

Concurrent use with corticosteroids may increase the likelihood of gastric ulcers. Similarly, co-administration with selective serotonin reuptake inhibitors (SSRIs) raises the risk of bleeding. Be mindful of these combinations and communicate openly with healthcare providers regarding all medications and supplements to ensure safety.

Recommendations for Safe Use

Consider taking aspirin with food to mitigate gastrointestinal irritation. Always follow dosage recommendations and avoid self-medicating, particularly in the presence of pre-existing conditions. Regular check-ins with a healthcare professional can enhance safety and adjust dosages based on individual health needs.

Accessing and Navigating the PubChem Database for Aspirin

To access information about aspirin on the PubChem database, visit the PubChem website at pubchem.ncbi.nlm.nih.gov. Once there, use the search bar at the top of the page. Enter “Aspirin” or its chemical name, “Acetylsalicylic Acid,” for precise results.

After submitting your query, you will see a list of related compounds. Click on the entry for aspirin, typically identified by its CID (Compound Identifier), which is 2244. This will direct you to a dedicated page containing comprehensive details, including chemical structure, molecular formula, and biological activities.

The page is divided into several sections:

Section	Description
Summary	Basic information about aspirin, including its uses and effects.
Chemical Structure	Visual representation of aspirin’s molecular structure.
Properties	Physical and chemical properties, such as molecular weight and solubility.
Biological Activities	Information on the pharmacological effects, targets, and mechanisms.
Safety and Toxicity	Data regarding potential hazards and toxicity levels.
References	Links to research articles and additional resources.

Explore each section for detailed insights. For chemical structure visualization, use the interactive tools provided to manipulate the 3D structure of aspirin. Utilize the “Download” option to access data in various formats, including SDF or MOL files for further analysis.

For more advanced searches, utilize the “Advanced Search” feature. Filter results by specific criteria such as biological activity, subtype, or receptor target. This will help you narrow down your research effectively.

If you encounter any difficulties, consult the help section of the PubChem site, which provides guidance on navigating the database and optimizing your searches.